Notes by Dr Kent’s on his canine Lymphoma Cancer research with Nanoparticles. Rearch funded by a grant from NCCF
Lymphoma in dogs is one of the most common cancers. While between 80 and 90% of dogs will achieve a complete remission, with conventional chemotherapy protocols the median time to loss of first remission is between 8 and 10 months with median overall survivals ranging between 12 and 14 months. Only about 5% of dogs will be alive at two years. The last major breakthrough for the treatment of canine lymphoma was the addition of doxorubicin to combination chemotherapy protocols around 30 years ago. New therapies to break through this ceiling are desperately needed.
We have recently begun enrolling dogs with relapsed lymphoma in a new clinical trial to evaluate a new type of chemotherapy treatment. We are evaluating response and toxicity. Working closely with the human medical school we have developed a nanoparticle targeting agent. This molecule targets dog lymphoma cells and brings conventional chemotherapy agents to the cancer cells. This has the potential of making therapy for lymphoma both more effective and less toxic.
This work is funded by a grant from the National Canine Cancer Foundation. At the conclusion of the trial we will make more information on this exciting new treatment available on the website
Tags: Cancer, Canine Cancer Research
June 23rd, 2009 at 11:30 am
Very helpful information. Thanks for this.